Abstract. Ozone profile measurements collected at L'Aquila (Italy, 42.4° N) during seventeen years of radio-sounding (2000–2016) are presented here, with an analysis of derived trends. Model results from the SPARC-CCMI exercise are used in parallel to highlight the physical and chemical mechanisms regulating mid-latitude ozone trends. The statistically significant trends highlighted in time series at L'Aquila are those in the mid-upper stratosphere (+5.9 ± 4.2), mid troposphere (+5.9 ± 2.4) and upper troposphere (+2.5 ± 0.9), all in percent/decade. The upper stratospheric positive trend was already well documented in recent WMO assessments and attributed to the starting decline of stratospheric Cl_y and Br_y and to the stratospheric cooling induced by increasing well mixed greenhouse gases, thus slowing down gas-phase reactions that destroy ozone in the upper stratosphere. The ozone increase in the mid-upper troposphere is largely regulated by the increasing strength of the Brewer-Dobson circulation, which moves more ozone from the tropics to the extratropics and enhances the tropospheric influx from the lowermost stratosphere. This climate feedback mechanism on tropospheric ozone is only partially compensated by the increasing chemical ozone loss associated to higher H₂O values in response to the tropospheric warming. We also note that ozone trends obtained in the lower stratosphere are negative (−2.2 percent/decade), but do not result to be statistically significant in our analyses.