<p>Ozone-vegetation feedback is essential to tropospheric ozone (O<sub>3</sub>) concentrations. The O<sub>3</sub> stomatal uptake damages leaf photosynthesis and stomatal conductance and, in turn, influences O<sub>3</sub> dry deposition. Further, O<sub>3</sub> directly influences isoprene emissions, an important precursor of O<sub>3</sub>. The effects of O<sub>3</sub> on vegetation further alter local meteorological fields and indirectly influence O<sub>3</sub> concentrations. In this study, we apply a fully coupled chemistry-carbon-climate global model (ModelE2-YIBs) to evaluate changes in O<sub>3</sub> concentrations caused by O<sub>3</sub>–vegetation interactions. Different parameterizations and sensitivities of the effect of O<sub>3</sub> damage on photosynthesis, stomatal conductance, and isoprene emissions (IPE) are implemented in the model. The results show that O<sub>3</sub>-induced inhibition of stomatal conductance increases surface O<sub>3</sub> on average by + 2.1 (+ 1.4) ppbv in eastern China, + 1.6 (− 0.5) ppbv in the eastern U.S., and + 1.3 (+ 1.0) ppbv in western Europe at high (low) damage sensitivity. Such positive feedback is dominated by reduced O<sub>3</sub> dry deposition, in addition to the increased temperature and decreased relative humidity from weakened transpiration. Including the effect of O<sub>3</sub> damage on IPE slightly reduces surface O<sub>3</sub> concentrations by influencing precursors. However, the reduced IPE weakens surface shortwave radiative forcing of secondary organic aerosols leading to increased temperature and O<sub>3</sub> concentrations in the eastern U.S. This study highlights the importance of interactions between O<sub>3</sub> and vegetation with regard to O<sub>3</sub> concentrations and the resultant air quality.</p>