Unexpectedly large seasonal phase differences between CH<sub>4</sub> concentration and its <sup>13</sup>C/<sup>12</sup>C isotopic ratio and their inter-annual variations observed in southern hemispheric time series have been attributed to the Cl+CH<sub>4</sub> reaction, in which <sup>13</sup>CH<sub>4</sub> is discriminated strongly compared to OH+CH<sub>4</sub>, and have provided the only and indirect evidence of a hemispheric-scale presence of oxidative cycle-relevant quantities of tropospheric atomic Cl. Our analysis of concurrent New Zealand and Antarctic time series of CH<sub>4</sub> and CO mixing and isotope ratios shows that a corresponding <sup>13</sup>C/<sup>12</sup>C variability is absent in CO. Using the AC-GCM EMAC model and isotopic mass balancing for comparing the periods of presumably high and low Cl, it is shown that variations in extra-tropical Southern Hemisphere Cl can not have exceeded 0.9 × 10<sup>3</sup> atoms cm<sup>−3</sup>. It is demonstrated that the <sup>13</sup>C/<sup>12</sup>C ratio of CO is a sensitive indicator for the isotopic composition of reacted CH<sub>4</sub> and therefore for its sources. Despite ambiguities about the yield of CO from CH<sub>4</sub> oxidation, with this yield being an important factor in the budget of CO, and uncertainties about the isotopic composition of sources of CO, in particular biomass burning, the contribution of Cl to the removal of CH<sub>4</sub> in the troposphere is probably much lower than currently assumed.