The processes of aerosol sulfate formation are vital components in the scientific understanding of perturbations of earth's radiative balance via aerosol direct and indirect effects. In this work, an analysis of the influence of changes in oxidant levels and sulfur dioxide oxidation pathways was performed to study the underlying pathways for sulfate formation. Sensitivities of this constituent were calculated from a series of photochemical model simulations with varying rates of NO_x and VOC emissions to produce variations in oxidant abundances using a photochemical model (CMAQ) that covers the Eastern US for the ICARTT 2004 campaign. Three different chemical mechanisms (CBIV, CB05, and SAPRC99) were used to test model responses to changes in NO_x and VOC levels. Comparison of modeled results and measurements demonstrates that the simulations with all three chemical mechanisms capture the levels of sulfate reasonably well. However, the three mechanisms are shown to have significantly different responses in sulfate formation when the emissions of NO_x and/or VOC are altered, reflecting different photochemical regimes under which the formation of sulfate occurs. Also, an analysis of the oxidation pathways that contribute to sulfur dioxide conversion to sulfate reveals substantial differences in the importance of the various pathways among the three chemical mechanisms. These findings suggest that estimations of the influence that future changes in primary emissions or other changes which perturb SO₂ oxidants have on sulfate abundances, and on its direct and indirect radiative forcing effects, may be dependent on the chemical mechanism employed in the model analysis.