A number of attempts have been made to incorporate sea-salt aerosols (SSA) source functions in chemistry transport models with varying results according to the complexity of the scheme considered. This contribution compares the inclusion of two different SSA algorithms in two chemistry transport models: CMAQ and CHIMERE. The main goal is to examine the differences in average SSA mass and composition and to study the seasonality of the prediction of SSA when applied to the Mediterranean area with high resolution in a reference year. Dry and wet deposition schemes are also analyzed to better understand the differences observed between both models in the target area. The applied emission algorithm in CHIMERE uses a semi-empirical formulation which obtains the surface emission rate of SSA as a function of the surface wind speed cubed and particle size. The emission parameterization included within CMAQ is somehow more sophisticated, since fluxes of SSA are corrected with relative humidity. In order to evaluate their strengths and weaknesses, the participating algorithms as implemented in the chemistry transport models were evaluated against AOD measurements from Aeronet and available surface measurements in Southern Europe and the Mediterranean area, showing biases around −0.003 and −1.2 μg m⁻³, respectively. The results indicate that both models represent accurately the patterns and dynamics of SSA and its non-uniform behavior in the Mediterranean basin, showing a strong seasonality. The levels of SSA vary strongly across the Western and the Eastern Mediterranean, reproducing CHIMERE higher annual levels in the Aegean Sea (12 μg m⁻³) and CMAQ in the Gulf of Lion (9 μg m⁻³). The large difference found for the ratio PM_2.5/total SSA in CMAQ and CHIMERE is also investigated. The dry and wet removal rates are very similar for both models despite the different schemes implemented. Dry deposition essentially follows the surface drag stress patterns, meanwhile wet deposition is more scattered over the continent. CMAQ tends to provide larger amounts of SSA dry deposition over the Northern Mediterranean (0.7–1.0 g m⁻² yr⁻¹), meanwhile the Southeastern Mediterranean accounts for the maximum annual dry deposition in the CHIMERE model (0.9–1.5 g m⁻² yr⁻¹). The wet deposition is dominated by the accumulation mode and is strongly correlated to the precipitation patterns, showing CMAQ a higher wet deposition/total deposition ratio over coastal mountain chains. The results of both models constitute a step towards increasing the understanding of the SSA dynamics in a complex area as the Mediterranean.